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- Pramipexole Stops MS in Animal Model – Helps Restless Legs, Fibromyalgia, and May Help Resistant Depression on
- Severe Neuropathic Pain – Only 1/4 Respond to Standard Drug Protocols – What Else Is There? on
- Office Ketamine For Chronic Pain Poster on
- Ganglion Impar Injection For Tailbone Coccydynia on
- Neuropathic Treatment Failure -The Greatest Issue In Treatment of Chronic Pain on
Category Archives: Drugs
A Fokl DNA gene polymorphism in the Vitamin D receptor would reduce its sensitivity to vitamin D. Vitamin D supports many metabolic processes beyond calcium and gene variations are even associated with certain cancers. In athletes, the FF Fokl genotype … Continue reading
Prior I wrote about a Dry Eye- Mouth Syndrome (DEMS) that has some joint involvement. DEMS is associated with thyoid antibodies suggesting an autoimmune process (1). Now It was found more commonly in irritable bowel, chronic pelvic pain and irritable … Continue reading
6-8 years ago a brief neuralgic pain in the scalp that radiated to front or back of head was described. I wrote about it here: http://painmuse.org/?p=1516 Now a facially originated version has been defined and sounds very much like trigeminal … Continue reading
Not all that long ago, Canadian Indian Affairs mandated that native pain sufferers had to try gabapentin/cymbalta like drugs first before certain opioids. I wrote about how poorly cymbalta worked: http://painmuse.org/?p=2179 Now even gabapentin failed to help back pain with … Continue reading
Many years ago I was injecting enbrel paraspinously near the nerve exit of sciatica nerve location. I was using a full 25 mg and found it had minimal effects. I wrote E. Tobinick at times and wondered if it was … Continue reading
CDC 2016 has put out a checklist for opioid use. It does not emphasize much on use of injection, manual medicine and other alternative techniques but does give some guidelines.
With Medical Marijuana, migraine frequency dropped from 10.4 to 4.6 headaches per month.
Recent study added lamotrigine to depressed subjects already under treatment. Folic acid supplementation appeared to prevent any improvement versus those not on supplementation.
I am trying to put together a list of steps for prescribing Marijuana. This is version 1.1 – please provide additional steps. Our province dos not cover this drug even for palliative care patients (yes, we are in a bible … Continue reading
A 25 yr old bipolar patient of mine was put on metformin and a weight loss program prior to hip surgery. Her mood was more stable and she noticed particularly fewer manic episodes. There is evidence in literature for metformin helping bipolar … Continue reading
Adenosine Monophosphate activated Protein Kinase (AMPK) regulates cell metabolism i.e “AMPK has a central regulatory role in cell metabolism, mitochondrial biogenesis and oxidative stress response”. Recent study of FM fibroblasts found AMPK downregulated.”AMPK down-regulation [is] at least in part responsible … Continue reading
Only study on Pine bark for migraine I could find used 1200 mg/day and did get impressive results on resistant migraines. But the best price I could get for that was $4/day..
In the US, a drug combination for treatment of migraines has been released called Treximet – sumatriptan (Imetrix) 10 mg and Aleve (Sodium Naproxen) 25 mg. It has been approved for use in adolescents 12-17. In Canada you’d have to … Continue reading
For Diabetic Neuropathy – Recent study in China showed statistical significant drop of pain on Duloxetine but not clinically significant. – Have a look.
Initial study showed benefit only in first 6 weeks more than placebo and not after: Study glowingly mentions early effects but fails to mention lack of lasting effects Comment – I recently reviewed a back study that cleverly disguised their … Continue reading
The initial study of use of Amitriptyline was a study with diabetic neuropathy where patients were subject to impressive coaching (calls from nurse and pharmacist) . That way doses of 75-150 mg were obtained. They were able to show benefits. … Continue reading
Using 6% gabapentin, 4% amitriptyline, ketoprofen 10%, lidocaine 5%, and ketamine 10% probably in Lipoderm could give some relief topically. Ketamine 100 mg/ml with 0.1 ml spray nasally could give additional relief. 30% mannitol might be good here.
Three IV Magnesium 1mg /k in 100 mls saline infusions over 1 hour – one every other day or Three 1 mg/kg Ketamine in 100 mls saline infused in over 1 hour ketamine one EOD resulted in 7/15 magnesium and … Continue reading
Finding high levels of beta2 adrenergic receptor autoantibodies in CRPS cases might explain why steroids, tumour necrosis factor (TNF)-alpha antagonist Adalimumab, IV Immmunoglobulins, and in present article Plasmapheresis can help in selected cases. In present study, these antibody titres fell … Continue reading
Neuropathic pain drugs by self have mediocre effects – often dropping pain by </= 2/10 points. At low dose Imipramine 75 mg/day and Pregabalin 300/day did not have significant benefit but the combo dropped VAS by One more than placebo … Continue reading
4000 u/d vitamin D lessening Chronic Musculoskeletal Pains
Mayo clinic has a review but lacks imagination
Donepezil (aricept) is used as an anticholinergic to help dementia. In the animal model repeated use can “cure” “ICS[Intermittent Cold Stress]-induced hyperalgesia [increased pain] and allodynia[touch pain] even after the cessation of drug treatments”
A Water pill, Spironolactone 100-200 mg/day, can dramatically relieve pain in potentially 1/2 of Fibromyalgia cases and reduce morphine needs.
Opioids can lower resistance to infections. Had on lady get couple of pneumonias which made me reconsider which types of opioids to use in these cases.