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Category Archives: Fibromyalgia
Both duloxetine and pregabalin work by restoring brain down pain inhibition. Hence the work in people who have deficits in this system. There is a simple test to confirm functioning.
In Hashimoto’s thyroiditis, quoted FM rate is 30-40% ; present study found 62%. Thyroid antibodies, abdominal girth, and duration disease among other things, contribute to FM possibility.
June 2017 Pain News: I put them up as short snaps because not going to blog note them – hope you like. You will probably not find many in news elsewhere.
A Fokl DNA gene polymorphism in the Vitamin D receptor would reduce its sensitivity to vitamin D. Vitamin D supports many metabolic processes beyond calcium and gene variations are even associated with certain cancers. In athletes, the FF Fokl genotype … Continue reading
Prior I wrote about a Dry Eye- Mouth Syndrome (DEMS) that has some joint involvement. DEMS is associated with thyoid antibodies suggesting an autoimmune process (1). Now It was found more commonly in irritable bowel, chronic pelvic pain and irritable … Continue reading
Twin study shows low Epiandrosterone, a metabolite of dehydroepiandrosterone (DHEA). Could supplementation help?
In seeing new pain patients, I became painfully aware that Celiac or at least gluten sensitivity has a definite presence- so much so that I always looked for it. Now, it looks like “anybody is fair game” now that even … Continue reading
Two important studies on approaches to help Fibromyalgia (FM) have omitted changes in Visual Analog Scale (VAS) readings in their results. Giving reading of skin tenderness adds differences with each muscle site tested and can exaggerate total difference. Suspicion is, … Continue reading
Adenosine Monophosphate activated Protein Kinase (AMPK) regulates cell metabolism i.e “AMPK has a central regulatory role in cell metabolism, mitochondrial biogenesis and oxidative stress response”. Recent study of FM fibroblasts found AMPK downregulated.”AMPK down-regulation [is] at least in part responsible … Continue reading
Widespread Pain and Dizzy – Ear Canalithiasis? (rocks) and Repositioning Them Helps Whiplash, TMJ, and Fibromylagia
Study suggests dizzy whiplash and widespread pain cases could respond well to middle ear grit repositioning measure. This is being able to see way outside the box…
Initial study showed benefit only in first 6 weeks more than placebo and not after: Study glowingly mentions early effects but fails to mention lack of lasting effects Comment – I recently reviewed a back study that cleverly disguised their … Continue reading
Old McGill study found initial impressions of doctors and rheumatologist were wrong 2/3 of time and in particular inflammatory arthritis cases are missed. Fitzcharles, M‐A et al. “Inaccuracy in the diagnosis of fibromyalgia syndrome: analysis of referrals.” Rheumatology 42.2 (2003): … Continue reading
Over the past couple years there is growing evidence that maybe 1/3 of Fibromyalgia patients actually suffer from non-celiac gluten sensitivity and respond to gluten free diet – some within a few month, and some “gradually… over many months”. Gluten … Continue reading
With help of EEG (scalp)sensors, one can measure a brain response to a stimulus- often auditory. Often the brain reaction diminishes with a repeat stimulus – called sensory gating. If one were hypervigilant, you would expect the brain response to … Continue reading
Myotonia Congenita is a rare neuromuscular disease manifest by “painful muscle cramps or myalgia as well as transient muscle weakness following myotonic stiffness”. Article describes 2 cases – one that got worse with pregnancy which is what Fibromyalgia also does. … Continue reading
4000 u/d vitamin D lessening Chronic Musculoskeletal Pains
Mayo clinic has a review but lacks imagination
A study found falls in FM related to reduced dorsiflexion (bringing toes and foot up). The question is how does one fix that.
Donepezil (aricept) is used as an anticholinergic to help dementia. In the animal model repeated use can “cure” “ICS[Intermittent Cold Stress]-induced hyperalgesia [increased pain] and allodynia[touch pain] even after the cessation of drug treatments”
A Water pill, Spironolactone 100-200 mg/day, can dramatically relieve pain in potentially 1/2 of Fibromyalgia cases and reduce morphine needs.
Implications have been made that victims of FM are nuts and think too much of their pain. Now it seems that subjects with FM are no better in awareness of changes in tactile stimulation – suggesting hypervigilance is not present.
Fibromyalgia – Part of “Software Malfunction” is Dopaminergic/GABAergic Neurotransmission Disruption
Excessive pain due to brain central sensitization has been called a “software malfunction”. Part of that appears to be of Dopa/GABA circuits.
Canada has no alternative (CAM) FM treatment recommendations but Isreali and German Recommendations do..
New Acceptance and Commitment therapy – 8 sessions of 2.5 hours reduced pain by 20% in 1/2 cases but only 50% in 1/48 cases. Fairly maximal drug therapies with pregabalin +/- Duloxetine alone was not great
I have recently achieved (previously unattainable) control in some of my chronic pain subjects using recent innovations – but to acheive this required use of multiple modalities at once.