Donepezil (aricept) is used as an anticholinergic to help dementia. In the animal model repeated use can “cure” “ICS[Intermittent Cold Stress]-induced hyperalgesia [increased pain] and allodynia[touch pain] even after the cessation of drug treatments”
J Pharmacol Exp Ther. 2015 Mar 24. pii: jpet.114.222414. [Epub ahead of print]
Donepezil reverses intermittent stress-induced generalized chronic pain syndrome
Mukae T(1), Uchida H(1), Ueda H(2).
Comment – study done in rats where donepezil introduced into brain so hard to generalize. Cognitive dysfunction is common in Fibromyalgia so question is whether Aricept might be a treatment option for that and for the widespread pain.