Donepezil reduces stress induced widespread pain in mice so…

Donepezil (aricept) is used as an anticholinergic to help dementia. In the animal model repeated use can “cure” “ICS[Intermittent Cold Stress]-induced hyperalgesia [increased pain] and allodynia[touch pain] even after the cessation of drug treatments”

J Pharmacol Exp Ther. 2015 Mar 24. pii: jpet.114.222414. [Epub ahead of print]
Donepezil reverses intermittent stress-induced generalized chronic pain syndrome
in mice.
Mukae T(1), Uchida H(1), Ueda H(2).

Comment  – study done in rats where donepezil introduced into brain so hard to generalize. Cognitive dysfunction  is common in Fibromyalgia so question is whether Aricept might be a treatment option for that and for the widespread pain. golden goose shoes golden goose shoes

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