here is poster in pdf format:
here is poster in pdf format:
GOOGLE TRANSLATE NOW ANY LANGUAGE ———————————————>
I have a program that tracks where users are from – pain is worldwide:
I have recently achieved (previously unattainable) control in some of my chronic pain subjects using recent innovations – but to acheive this required use of multiple modalities at once.
Over three minute pressure to occipital arteries can greatly relieve migraine pain in over 1/2 of cases; almost sounds too good to be true. Continue reading
Hyperpolarization-activated cyclic nucleotide-gated (HCN2) channels have been found to cause issues in animal models of diabetic neuropathy and the rush is on to find a drug safe to use to block them.
I was asked to put a letter in a time capsule for my great nephew. I reflected over the near 40 years I have been working on chronic pain and my wishes for 2034. The treatment of neuropathic pain is an issue in which breakthroughs have to occur. I suspect genetic manipulation of gene activation levels (especially in the spine) could play a role because otherwise, up to now, treatments have failed to work well.
(Note – the picture reflects radiculitis which amounts to over 1/2 of neuropathic patients)
Imipramine drops polyneuropathy pain by one and has no increasing effect with dosage suggesting most effect is placebo. Pregabalin drops pain by 0.4 and marginal/not significant drug dosing effects suggesting neither is much use alone.
Magnesium oxide is (surprisingly) better absorbed than citrate –
Comparison of magnesium status using X-ray dispersion analysis following magnesium oxide and magnesium citrate treatment of healthy subjects.
Shechter, Michael, et al.
Magnesium research 25.1 (2012): 28-39.
Comment _ I now tell patients to take whatever magnesium is cheapest and take it to point just before they get diarrhea.
It is proposed that PTSD and abnormal grief reactions are due to mal-wired brain connections that loop painful recollections.
In phantom limb, abnormal circuit changes potentiate the pain. Some of these connections can be over-written by “mirror therapy” where a mirror is placed so that missing limb is mirrored and limb movement is registered in brain as happening in missing limb. Repeated 10 minute session could have an impact.
“Mirror” therapy is similarly used in abnormal grief and PTSD and in a couple of cases noted improvements after two session.
This is a newly described condition. Ignored as a possible cause of head pain (astoundingly, 6/15 had a prior supraorbital nerve block but not trochlear). Tip off is it’s near midline location. Pressing or stabbing is the usual nature and 9/15 had an intermittent nature with great variability and length. Inner upper orbital rim is tender.
4/15 had bilateral pains, making it more difficult to access. 3-5/15 got lasting effects from blocks; no one drug was consistently used.
Using vinager for hiccups is a Japanese folk medicine treatment. After testing in regular subjects for safety, 0.1 ml; of vinerger (4.2% acetic acid) was used in a cancer patient with persistent hiccups with effect.
Putting together info on using newer agents. Note: DPP4 and SGLT2 combo not allowed by EDS. Lectures from Dr. Sue Petersen 2017
If you take cases of cervical radiculitis – if imaging shows possible reason for it, they give a history of having had shingles at about 18.4%. In cases with normal imaging, the prior incidence jumps to 81.6% (p<0.01) – most of them not within the last 24 months. This leaves one to wonder if the virus had some input into this disease or whether abnormal autoantibodies contributes to some autoimmune syndrome.
Patients were followed during various stages of chemotherapy. and had 1/4 or less significant mucositis compared to control if took Zinc Sufate 220 mg/day
Below is a recent email of someone with multisystem undiagnosed problems that would be daunting to say the least;
In rat model, vitamin C prevents oxidative stress on liver and kidney
Though often confused with an abscess, acute anterior neck pain and stiffness associated with swallowing pain or globus, can be longus colli tendonitis. Calcificatrions might be seen on xray. Fortunately it last only a couple weeks on average
in the Animal model if animal sleep deprived ( Not fragmented sleep though) , they animals become more sensitive to noxious stimuli. Yet sleep would restore things and Caffeine would also reduce pain reaction.
Both duloxetine and pregabalin work by restoring brain down pain inhibition. Hence the work in people who have deficits in this system. There is a simple test to confirm functioning.
Friedrich Nietzsche – What I got out of his Sayings
Keyboard too close, too long in one job position, and muscle tension are 3 factors found in one study
Twin study found only a weak relationship between sedentary lifestyle and chronic back pain – and found it only in women and when corrected for genetics -was only weak.
In Hashimoto’s thyroiditis, quoted FM rate is 30-40% ; present study found 62%. Thyroid antibodies, abdominal girth, and duration disease among other things, contribute to FM possibility.
Must be horrible to have a sore mouth with chemotherapy – ketamine 20 mg/5ml used four times daily reduced pain from 6 to 3 within days.
“Sedative-hypnotic use compared with nonuse was associated with 6.4 times the risk of opioid overdose death. … Even at opioid doses 1-19 mg/d, patients using sedative-hypnotics concurrently had 5.6 times the risk than patients without sedative-hypnotics”. I must admit I have found clonazepam helpful for restless legs and sleep but cannot bring myself to allow sedative use with these sort of statistics.
Low dose Radiotherapy over age 70 has minimal risks but can often drop pain by 1.9/10 in following issues – sore heel and achilles pains, knee pains, and trochanteric bursitis.
Spine J. 2017 Jul;17(7):905-912. doi: 10.1016/j.spinee.2017.02.009.
Chronic low back pain and the risk of depression or anxiety symptoms: insights
from a longitudinal twin study.
“The relationship between chronic LBP and the future development of depression or anxiety symptoms is not causal.”
Shared familial factors was considered more likely
Child cancer case where chemotherapy induced peripheral neuropathy pain was not helped by usual topicals was helped by 5% doxepin cream