Acute Nerve Injury – Fasting and No NSAID’s

Fasting promotes growth of Clostridium sporogenes which elevates levels of indole-3-propionic acid (IPA).  In mouse model, improves “promotes neutrophil infiltration into the dorsal root ganglia (DRG), which enhances the regeneration of sciatic nerve fibers”.

Nerve growth is contingent on a type of neurophils (and also a type of macrophages). Arthritis Pills/NSAIDs would interfere with that.

I sustained injury to the back skin nerves (cluneal) and I stayed off NSAID for  6 weeks to allow nerves to regrow. Tramadol would be a good option in meantime.

I tried some fasting but can’t say if helped.

Kurtovic, Z., Svensson, C.I. & Krock, E.
Bugs improve nerve regeneration: fasting-induced, microbiome-derived metabolite enhances peripheral nerve regeneration.
Sig Transduct Target Ther 7, 351 (2022)
https://www.nature.com/articles/s41392-022-01186-6#citeas

Mentioned recently:

Sisignano, Marco, and Gerd Geisslinger.
Rethinking the use of NSAIDs in early acute pain.
Trends in Pharmacological Sciences (2023)
Science & Society| Volume 44, ISSUE 4, P193-195, April 202
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(23)00016-0

 

 

This entry was posted in Uncategorized. Bookmark the permalink.

Leave a Reply

Your email address will not be published.