Author Archives: admin
Hyperpolarization-activated cyclic nucleotide-gated (HCN2) channels have been found to cause issues in animal models of diabetic neuropathy and the rush is on to find a drug safe to use to block them. An Ion Channel That Perpetuates Pain in Diabetic … Continue reading
I was asked to put a letter in a time capsule for my great nephew. I reflected over the near 40 years I have been working on chronic pain and my wishes for 2034. The treatment of neuropathic pain is … Continue reading
Imipramine drops polyneuropathy pain by one and has no increasing effect with dosage suggesting most effect is placebo. Pregabalin drops pain by 0.4 and marginal/not significant drug dosing effects suggesting neither is much use alone.
Magnesium oxide is (surprisingly) better absorbed than citrate – Comparison of magnesium status using X-ray dispersion analysis following magnesium oxide and magnesium citrate treatment of healthy subjects. Shechter, Michael, et al. Magnesium research 25.1 (2012): 28-39. http://www.jle.com/download/mrh-292422-comparison_of_magnesium_status_using_x_ray_dispersion_analysis_following_magnesium_oxide_and_magnesium_citrate_treatment_of_healthy_s–Whrf@H8AAQEAACBLEjMAAAAL-a.pdf Felt that … Continue reading
It is proposed that PTSD and abnormal grief reactions are due to mal-wired brain connections that loop painful recollections. In phantom limb, abnormal circuit changes potentiate the pain. Some of these connections can be over-written by “mirror therapy” where a … Continue reading
This is a newly described condition. Ignored as a possible cause of head pain (astoundingly, 6/15 had a prior supraorbital nerve block but not trochlear). Tip off is it’s near midline location. Pressing or … Continue reading
Using vinager for hiccups is a Japanese folk medicine treatment. After testing in regular subjects for safety, 0.1 ml; of vinerger (4.2% acetic acid) was used in a cancer patient with persistent hiccups with effect.
Putting together info on using newer agents. Note: DPP4 and SGLT2 combo not allowed by EDS. Lectures from Dr. Sue Petersen 2017
If you take cases of cervical radiculitis – if imaging shows possible reason for it, they give a history of having had shingles at about 18.4%. In cases with normal imaging, the prior incidence jumps to 81.6% (p<0.01) – most of … Continue reading
Patients were followed during various stages of chemotherapy. and had 1/4 or less significant mucositis compared to control if took Zinc Sufate 220 mg/day
Below is a recent email of someone with multisystem undiagnosed problems that would be daunting to say the least;
In rat model, vitamin C prevents oxidative stress on liver and kidney
Though often confused with an abscess, acute anterior neck pain and stiffness associated with swallowing pain or globus, can be longus colli tendonitis. Calcificatrions might be seen on xray. Fortunately it last only a couple weeks on average
in the Animal model if animal sleep deprived ( Not fragmented sleep though) , they animals become more sensitive to noxious stimuli. Yet sleep would restore things and Caffeine would also reduce pain reaction.
Both duloxetine and pregabalin work by restoring brain down pain inhibition. Hence the work in people who have deficits in this system. There is a simple test to confirm functioning.
Friedrich Nietzsche – What I got out of his Sayings
Keyboard too close, too long in one job position, and muscle tension are 3 factors found in one study
Twin study found only a weak relationship between sedentary lifestyle and chronic back pain – and found it only in women and when corrected for genetics -was only weak.
“Severe high altitude headache occurred in 3% treated with ibuprofen and 10% with placebo”
In Hashimoto’s thyroiditis, quoted FM rate is 30-40% ; present study found 62%. Thyroid antibodies, abdominal girth, and duration disease among other things, contribute to FM possibility.
Must be horrible to have a sore mouth with chemotherapy – ketamine 20 mg/5ml used four times daily reduced pain from 6 to 3 within days.
“Sedative-hypnotic use compared with nonuse was associated with 6.4 times the risk of opioid overdose death. … Even at opioid doses 1-19 mg/d, patients using sedative-hypnotics concurrently had 5.6 times the risk than patients without sedative-hypnotics”. I must admit I have … Continue reading
Certain Orthopedic Issues over 70 yr Old – Easy Pain Help – low Dose Radiotherapy- But Will you ever see it?
Low dose Radiotherapy over age 70 has minimal risks but can often drop pain by 1.9/10 in following issues – sore heel and achilles pains, knee pains, and trochanteric bursitis.
Spine J. 2017 Jul;17(7):905-912. doi: 10.1016/j.spinee.2017.02.009. Chronic low back pain and the risk of depression or anxiety symptoms: insights from a longitudinal twin study. Fernandez M https://www.ncbi.nlm.nih.gov/pubmed/28267634 “The relationship between chronic LBP and the future development of depression or anxiety … Continue reading
Child cancer case where chemotherapy induced peripheral neuropathy pain was not helped by usual topicals was helped by 5% doxepin cream