Topical anti-inflammatory drug would be the safest way to go in knee arthritis for example. Yet the number of patients needed to treat to help one case was
Ketoprofen – one in 6.9 cases
Diclofenac (Voltaren) – one in 9.8 cases
Orthop Nurs. 2017 Mar/Apr;36(2):161-163. doi: 10.1097/NOR.0000000000000331.
Topical Nonsteroidal Anti-Inflammatory Drugs for Chronic Musculoskeletal Pain in
“Topical diclofenac and topical ketoprofen can provide good levels of pain relief in
knee osteoarthritis in people older than 40 years but only in about 10% more people than with placebo.”
Comment – article suggests it might be useful in Chondromalacia patella and knee pains over 40 maybe try. I only use where desperate. Prolotherapy to knee, perineural Saphenous nerve tract D5W injections with Saphenous nerve blocks are alternatives for resistant cases.