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Category Archives: neuropathic
Concise choice selections for what to do with nerve damage level post hernia pains. I love algorithms – they are so practical.
Three IV Magnesium 1mg /k in 100 mls saline infusions over 1 hour – one every other day or Three 1 mg/kg Ketamine in 100 mls saline infused in over 1 hour ketamine one EOD resulted in 7/15 magnesium and … Continue reading
Study in Dermatology journal suggests 1/5 of subjects test positive with quiz DN4 for neuropathy
Finding high levels of beta2 adrenergic receptor autoantibodies in CRPS cases might explain why steroids, tumour necrosis factor (TNF)-alpha antagonist Adalimumab, IV Immmunoglobulins, and in present article Plasmapheresis can help in selected cases. In present study, these antibody titres fell … Continue reading
Neuropathic pain drugs by self have mediocre effects – often dropping pain by </= 2/10 points. At low dose Imipramine 75 mg/day and Pregabalin 300/day did not have significant benefit but the combo dropped VAS by One more than placebo … Continue reading
I have heard of peripheral nerve stimulators used in cases before but this additional one makes it more mainstream. This one captured control with high frequency
Case Burning Mouth Syndrome under 6 month old was found to have high herpesvirus DNA in saliva, and improved with herpesvirus treatment (which also cleared the DNA from saliva)
Mayo clinic has a review but lacks imagination
A sustained 40% improvement was obtained from direct current 1.5 milliamp voltage – about what a 9 volt battery hooked up with a 10 k potentiometer resistor could furnish.
A Water pill, Spironolactone 100-200 mg/day, can dramatically relieve pain in potentially 1/2 of Fibromyalgia cases and reduce morphine needs.
Use of Tricyclic antidepressants (TCA)’s for neuropathic pain was based on an article for diabetic neuropathy where, through frequent phoning and support, authors were able to get patients up to 150 mg. No one has succeeded in getting people up … Continue reading
Should we believe these results? A study on treatment for diabetic neuropathy pretends one treatment is better than onother because on group starts with more severe pain than the other then claims each treatment can virtually eliminate pains with 7 … Continue reading
Use of agents to reduce chemotherapy induced peripheral neuropathy confounded by issues of decreased anti-cancer effectiveness. L-Acetyl Carnitine during chemotherapy, and Venlafaxine or Duloxetine after are my choices. Tricyclics, gabapentin, lyrica, and topical agents did not rate well and belie … Continue reading
I have recently achieved (previously unattainable) control in some of my chronic pain subjects using recent innovations – but to acheive this required use of multiple modalities at once.
For years, it was suggested that people with carpal tunnel should take B6, but it fell out of favour ( in my mind) when excessive B6 was found to be neurotoxic. Now a recent study has confirmed use of B6 … Continue reading
saphenous neuralgia is not uncommon – here is how to free it up (floss it)
Recently, nortriptyline has been touted as good anti-neuropathic drug but thoughts of its use have extended into use for chronic pain in general. Well, it doesn’t work for back pain, sciatica or migraines so that might need reanalysis.
After classic sciatic nerve constriction in rats, spinal/nerve elevations of Tumor Necrosis Factor (TNF), matrix metalloproteases (MMP-2) and nerve growth factor (NGF) were some ameliorated by Atorvastatin. In a human case report, atorvastatin reduced neuropathic pain.
With Both neuropathic level pains, and paresthesias common in Fibromyalgia; the idea Fibromyalgia is a small fiber neuropathy, was presented in 2010. Now an extremely thorough followup was presented again confirming this issue. They found a a “pathological process involving … Continue reading
Neurobiol Dis. 2013 Dec;60:39-50.Antidepressants suppress neuropathic pain by a peripheral β2-adrenoceptor mediated anti-TNFα mechanism. Bohren Y, Tessier LH, Megat S, Petitjean H, Hugel S, Daniel D, Kremer M, Fournel S, Hein L, Schlichter R, Freund-Mercier MJ, Yalcin I, Barrot M. … Continue reading
Review has concluded both subcutaneous and perineural treatments are effective in neuropathic pains.
Combo Pregabalin(lyrica) and Duloxetine(Cymbalta) was able to control paclitaxel induced peripheral neuropathy.
Five cases of groin pain that refused deliniation and had NO back pains. They all turned out to be L4/5 or L5/S1 disc pain found on discogram/discoblock. They all got relief with anterior intrabody fusion.
Subject treated for acromegaly developed peripheral neuropathy and could not tolerate oral meds. Though pain was 9/10; 5% baclofen once daily, profoundly reduced pains in legs.
Non-diabetic painful numbness in hands/feet is often caused by inflammatory neuropathy. Tremor is common in these disorders and does not respond to usual treatments