January 2, 2017 at 4:32 am #5080
I am writing up a poster about using ketamine in severe pain patients. During the process, I found about an 80% incidence of Major Mood disorder(MMD)((longstanding history of anxiety-depression, some had hypomanic episodes as teenager, serious features depression). I thought this was because ketamine would help both the pain and moods. However, there is an article in press(1) stating:
“Participants with neuropathic pain were more likely to have a
coprevalent psychiatric condition than those with other pain types
(86% vs 26% for nociceptive and 32% for possible neuropathic
pain, P < 0.0001) and more likely to experience severe levels of disability related to their condition" This corresponds very well with my results. There is evidence that there is mitochondrial issues and pyruvate kinase enzyme issues in major depression and I wonder if nerves, spinal cord and brain does not repair properly after injury in MMD. Does bring up suggestions: 1) Use of frequent B12 shots to increase mitochondrial function- helps pain and mood 2) Use of transcranial magnetic stimulation in cases of chronic pain - re depression as I'm not impressed with antidepressants here. 3) I have been trying Palmitoylethanolamide (PEA) 400 mg 3 times daily for neuropathic pain with some success(2). 4) I already mentioned repeated Ketamine Injections which helps pain, mood and quality of life (for more - await my poster) 1)Liu, Richard, et al. "Classification and Treatment of Chronic Neck Pain: A Longitudinal Cohort Study." Regional Anesthesia and Pain Medicine 42.1 (2017): 52-61. http://journals.lww.com/rapm/Abstract/2017/01000/Classification_and_Treatment_of_Chronic_Neck_Pain_.8.aspx
2)Einaudi, Via Luigi, and Giustino Varrassi. “Palmitoylethanolamide, a special food for medical purposes, in the treatment of chronic pain: a pooled data meta-analysis.” Pain physician 19 (2016): 11-24.
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