I’m a big advocate of B12 for nerve damage pain but have added B6 to my regimen as came across article using it for drug induced neuropathy. Been previously shown to help carpal tunnel symptoms. B6 is touchy as 400 mg can cause nerve damage so best stick to 100 mg/day.
Meadows GG, Huff MR, Fredericks S.
Amitriptyline-Related Peripheral Neuropathy Relieved during Pyridoxine Hydrochloride Administration.
Drug Intelligence & Clinical Pharmacy. 1982;16(11):876-877
https://journals.sagepub.com/doi/abs/10.1177/106002808201601114?journalCode=aopb
- paresthesias induced by amitriptyline disappeared with B6
I wrote about B6 and carpal tunnel here:
Carpal Tunnel Syndrome and Vitamin B6
Comment – a series of German studies which used pyridoxine 50 mg and also thiamine 50 mg
Z Rheumatol. 1988 Sep-Oct;47(5):351-62.
Shortening diclofenac therapy by B vitamins. Results of a randomized double-blind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes.
Vetter G, Brüggemann G, Lettko M, Schwieger G, Asbach H, Biermann W, Bläsius K,
Brinkmann R, Bruns H, Dorn E, et al. abstract here
- diclofenac (50 mg) and vitamins B1 50 mg, B6 50 mg, B12 0.25 mg,3 X 1 capsule daily for 2 weeks versus just diclofenac
- “After 3 days of treatment, a statistically significant higher proportion of subjects in
Group DB (n = 87; 46.5%) than in Group D (n = 55; 29%) terminated the study due
to treatment success (chi(2): 12.06; p = 0.0005). Furthermore, the combination
therapy yielded superior results in pain reduction, improvement of mobility and
functionality. “
For acute back pain:
Klin Wochenschr. 1990 Jan 19;68(2):116-20.
Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus
diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter
study.
Brüggemann G, Koehler CO, Koch EM. abstract here
results seemed to be statistically better with those in severe pain initially
More recently, this style of study was repeated in a randomised, double blind controlled clinical study in parallel:
Curr Med Res Opin. 2009 Nov;25(11):2589-99.
Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR
study.
Mibielli MA, Geller M, Cohen JC, Goldberg SG, Cohen MT, Nunes CP, Oliveira LB, da
Fonseca AS. abstract here
- used diclofenac 50 mg twice daily or 50 mg diclofenac plus 50 mg thiamine,
50 mg pyridoxine and 1 mg cyanocobalamin twice daily - Results:
I have been taking b6 100 mg and mega dose of B12 and can now sleep on an arm without it going to sleep…