Exciting discovery! Hydroxymethylglutaryl-CoA (HMG-CoA) Reductase is involved in cholesterol metabolism and cholesterol pills block that enzyme. People with a less functioning version of that enzyme ended up with statin induce myopathy according to one study. Another study found it implicated in some limb-girdle muscular dystrophy and treatable with a compound that helps this enzyme – called oral mevalonolactone.
Yogev, Yuval, et al.
Limb girdle muscular disease caused by HMGCR mutation and statin myopathy treatable with mevalonolactone.
Proceedings of the National Academy of Sciences 120.7 (2023): e2217831120.
https://www.pnas.org/doi/full/10.1073/pnas.2217831120
News brief written recently:
https://www.theatlantic.com/health/archive/2023/06/the-gene-that-explains-statins-most-puzzling-side-effect/674542/?utm_source=pocket-newtab
Drug probably now available yet but could be a godsend for some in the future. Said to be well tolerated.