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Category Archives: Fibromyalgia
Fibromyalgia – Part of “Software Malfunction” is Dopaminergic/GABAergic Neurotransmission Disruption
Excessive pain due to brain central sensitization has been called a “software malfunction”. Part of that appears to be of Dopa/GABA circuits.
Canada has no alternative (CAM) FM treatment recommendations but Isreali and German Recommendations do..
New Acceptance and Commitment therapy – 8 sessions of 2.5 hours reduced pain by 20% in 1/2 cases but only 50% in 1/48 cases. Fairly maximal drug therapies with pregabalin +/- Duloxetine alone was not great
I have recently achieved (previously unattainable) control in some of my chronic pain subjects using recent innovations – but to acheive this required use of multiple modalities at once.
20.8% of post breast cancer sufferers were diagnosed with widespread pain and 10% with frank Fibromylgia.
Study finds erythrocyte magnesium levels are low in Fibromyalgia though adding it to amitriptyline had no additional benefit on pain. By self, pain reduction was not clinically significant.
Brain loss with Fibromyalgia (FM) is well known in elderly. What is new is the finding of brain growth in younger subjects – in Insula and basal ganglia – perhaps in attempt to control pain.
At a recent conference, I was given free samples of Myer’s Cocktail. Unfortunately, placebo controlled trial of 8 weekly infusions showed no benefit over placebo in Fibromyalgia. A trial of IV magnesium failed as well. Neither used glutathione so can’t … Continue reading
With Both neuropathic level pains, and paresthesias common in Fibromyalgia; the idea Fibromyalgia is a small fiber neuropathy, was presented in 2010. Now an extremely thorough followup was presented again confirming this issue. They found a a “pathological process involving … Continue reading
Fibromyalgia(FM) – Quetiapine XR (Seroquel) Reduces Pain Similar to Others and Reduces Depression – But Drowsiness High
FM could be considered a neurodegenerate disorder with certain degrees of brain loss and cognitive impairment evident. Some years ago I was at a presentation in which the brain damage evident in Fibromyalgia was bemoaned by speaker. Having dealt with … Continue reading
Occipital Stimulation dropped FM pains from 8/10 to 5/10 while placebo only decreased it from 8/10 to 7/10.
When pain becomes severe, constant, and unremitting – chances are high the pain has imprinted on the brain and centralized. This is a tragic disease with poor treatment options. In those that persisted with treatment (failures may have dropped out?) … Continue reading
1 hour/day of classic music mixed with salsa music resulted in a 24% reduction of pain over placebo. this is a confirmation of a different study finding relief with regular music listening: Music Therapy in Chronic Pain May Drop Pains … Continue reading
Presentation at Canadian Pain Society Winnipeg 2013 found only 23.7% of severe neuropathic pain victims responded to Canadian Pain Society drug protocols for neuropathic pain. It is time to look outside the box for treatment measures.
Though results have varied, latest studies show little benefit of guided imagery in FM.
Analysis of 41 cases of juvenile widespread pain found “definite SFPN (small fiber polyneuropathy) in 59%, probable SFPN in 17%, and possible SFPN in 22%. Steroids or IV gamma globulin subjectively helped 80% of those that tried them.
Naltrexone is a partial pain site blocker/stimulant used primarily to help alcoholics get off drinking. It was found in a controlled pilot study some years ago to help with pain in Fibromyalgia. It was well tolerated. Present controlled unfortunately shows … Continue reading
Fibromyalgia (FM) Cases with Tingly, Funny Feelings – How Can You Tell If You Have a Small Fiber Neuropathy Instead?
There is evidence that a small fiber neuropathy is responsible for a subset of FM cases – particluarly if there is more burning, numb feelings and severe pain (neuropathic symptoms). A group with these symptoms was biopsied but predicting who … Continue reading
Brain EEG “imaging” study shows hyperarousal with just brushing of right arm – highlighting fact disease involves brain hypersensitivity
Both FM and CBP are thought to, in part, involve central sensitization and inoperative descending pain inhibition. Their histories are however different.
Mice who are not physically active develop “exercise-induced muscle pain by reducing phosphorylation of the NR1 subunit of the NMDA receptor in the central nervous system.” – ie the pain circuits are hyperacute (or less protected depending on which way … Continue reading
Neck Pains and Widespread Problems like Fibromyalgia(FM) – When and Where To get an Upright Flexion/Extension MRI..
The only traumatic cause of Fibromylagia is Motor Vehicle Accidents . see Fibromyalgia Is Only Induced by Motor Vehicle Trauma ?Whiplash Disease Makes one think whiplash and neck damage are involved in FM. Neurolgical findings of neck spine damage (cervical … Continue reading
In 2006, My Daughter, Janice Montbriand, published a poster called Commonly Missed Factors in Chronic Pain. Vitamin D deficiency was one of them. Since the there have been a variety of confirmatory studies – with some negative ones as well. I … Continue reading
My daughter, Janice Montbriand, and I did a sleep study on selected cases of chronic pain and found a high incidence of sleep apnea. In Fibromylagia, disordered breathing (a dumbed down version of sleep apnea),is very common. Though the CPAP … Continue reading
The new Fibromyalgia criteria are confusing and so I put together a self- questionnaire that might simplify things for people.