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Do IV “Cocktails” work in Fibromyalgia?
At a recent conference, I was given free samples of Myer’s Cocktail. Unfortunately, placebo controlled trial of 8 weekly infusions showed no benefit over placebo in Fibromyalgia. A trial of IV magnesium failed as well. Neither used glutathione so can’t … Continue reading
Posted in Fibromyalgia, IV therapy
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Could Statins Help Prevent or Treat Neuropathy?
After classic sciatic nerve constriction in rats, spinal/nerve elevations of Tumor Necrosis Factor (TNF), matrix metalloproteases (MMP-2) and nerve growth factor (NGF) were some ameliorated by Atorvastatin. In a human case report, atorvastatin reduced neuropathic pain.
Posted in Drugs, neuropathic
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Could Fetal Alcohol Syndrome Be Prevented by Supplements Used to Prevent Alcoholic Neuropathy?
B12, coenzyme Q10 and Vitamin E have amiolorative effects on Alcoholic Neuropathy – could they help prevent some brain damage brought on by drinking?
Posted in Uncategorized
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Fibromyalgia – Further Elucidation of Small Fiber Neuropathy Presence.
With Both neuropathic level pains, and paresthesias common in Fibromyalgia; the idea Fibromyalgia is a small fiber neuropathy, was presented in 2010. Now an extremely thorough followup was presented again confirming this issue. They found a a “pathological process involving … Continue reading
Posted in Fibromyalgia, neuropathic
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Antidepressants Just Don’t Work on Descending Inhibition
Neurobiol Dis. 2013 Dec;60:39-50.Antidepressants suppress neuropathic pain by a peripheral β2-adrenoceptor mediated anti-TNFα mechanism. Bohren Y, Tessier LH, Megat S, Petitjean H, Hugel S, Daniel D, Kremer M, Fournel S, Hein L, Schlichter R, Freund-Mercier MJ, Yalcin I, Barrot M. … Continue reading
Posted in Drugs, neuropathic, Uncategorized
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C-section Birth – Is Painful Uterine Scar Bad – a Bit
1/10th of painful uterine scars will rupture; none in the non painful group. However all rupturing cases had other features – abnormal fetal monitor (4), peritoneal signs (2), high fetal station (2) or vomiting(1).
Posted in Abdominal pain
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Chronic Diarrhea? -Think Bile Malabsorption(BAM)
“The estimated prevalence of BAM is >90% in patients with resected Crohn disease (CD) and 11% to 52% of unresected CD patients (type 1); 33% in diarrhea-predominant irritable bowel syndrome (type 2); and is a frequent finding postcholecystectomy or postvagotomy … Continue reading
Posted in Abdominal pain
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Both Subcutaneous and Perineural Botulinum Treatments Advocated
Review has concluded both subcutaneous and perineural treatments are effective in neuropathic pains.
Posted in Botox, Drugs, neuropathic
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Chemotherapy Neuropathy – Drug Combo Helps Pains
Combo Pregabalin(lyrica) and Duloxetine(Cymbalta) was able to control paclitaxel induced peripheral neuropathy.
Posted in breast cancer, neuropathic
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Fibromyalgia(FM) – Quetiapine XR (Seroquel) Reduces Pain Similar to Others and Reduces Depression – But Drowsiness High
FM could be considered a neurodegenerate disorder with certain degrees of brain loss and cognitive impairment evident. Some years ago I was at a presentation in which the brain damage evident in Fibromyalgia was bemoaned by speaker. Having dealt with … Continue reading
Posted in central & spinal, Fibromyalgia, pain mechanisms
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MRI in Sports Hernia – Looks Into Cause But Does Not Change Treatment
Always wondered if imaging sports herniaas much help – apparently not much help in treatment. Older study but their conclusion: – ” MRI revealed a variety of pathological findings in athletes suffering from chronic groin pain, but it was not reliable … Continue reading
Posted in groin pain
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B12 Levels Might Be Important in Ketamine Response to Depression
Recent study demonstrated more favorable response to ketamine for depression if B12 levels are higher. I have been giving 1000 mcg/week IM and perhaps that is wise..
Posted in Depression
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14 Days Ketamine Induced Persistent Depression Relief in Adolescent Rats – and Maybe Relief in Resistant Depression
Depression was induced in rats by Forced swim procedure followed by “chronic unpredictable stress”. Control group did not recover. Rats subjected to 15 days of ketamine – were still good 2 months later, suggesting lasting results could be obtained but how … Continue reading
Posted in Depression
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Autologous Whole Blood Almost as Good as Platelet Rich Plasma in Chronic Tennis Elbow – And Alot Cheaper
Went to recent program that stated that though there were studies that showed no difference – there was one that did when injecting Platelet Rich Plasma versus using once spin down plasma (Autologous Whole Blood) The improvement was only statistically … Continue reading
Posted in Tennis elbow, Uncategorized
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Would Small Amounts of Lithium Help the Brain- Maybe
In Lancet 2000, it was found that there could be a 3% increase in grey matter with 1 month of of lithium therapy. Sadly, it is not that easy. Some say it would take 300+ mg/day to do anything though … Continue reading
Posted in Uncategorized
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Medial Femoral Condyle Knee OA – Is a Medial Plica the Cause?
Removal of the medial plica in cases of symptomatic plica with femoral condyle OA resulted in 88% excellent results at 6 months and 94% excellent results at 1 year. Conclusion was the plica was helping precipitate the OA.
Posted in Knee
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Knee Osteoarthritis – Both Band Resistance Training and “Home-based Kinesthesia, Balance and Agility” (KBA) Training Help Knee Pains But Combo No Better Than Either
You can reduce knee pains at home by 1/3 – 1/2 with exercises or balance trainings but the combo does not add anything to it.
Posted in Knee
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Distraction Technique For Osteoarithitis Knee For Young and Desperate
Putting pins below and above knee and then applying a traction device – for two months greatly relieves subsequent pain and allows cartilage regrowth. Most got some pin infection that required antibiotics at time.
Fibromyalgia – Occipital Stimulation Drops Pains 2 Points on VAS Scale vs Placebo
Occipital Stimulation dropped FM pains from 8/10 to 5/10 while placebo only decreased it from 8/10 to 7/10.
Posted in Fibromyalgia
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Geriatric Rotator Cuff Tears – Intra-articular Shoulder Joint Steroid Injection For Pain Control
Recently, had an elderly but otherwise in good condition patient with tears of two of his shoulder rotator cuff tendons that he wished repaired. Was told by specialist – too far gone – and just learn to live with it. … Continue reading
Posted in shoulder
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Taping Knees in Osteoarthritis- and Maybe Kneecap Pains
Knee taping can be self done and may reduce knee pains.
Canker Sore – One Shot Treatment
Grind up a doxycyline tablet, put some on a denture adhesive and stick it on sore – one application doubles pain relief over time
Posted in ENT
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New treatment For Chronic Insomnia – But Might Be Too Sticky For Some
Special Chimsband taping in a couple chronic cases helped with sleep but I suspect won’t catch on here..
Posted in Sleep
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Increased Connection Of Medial Prefrontal Cortex to Nucleus Accumbens(pleasure center) Predicts Chronic Pain
Saw recent talk by Dr. Apkarian where he noted overactivity of nucleus accumbens (pleasure center) in chronic pain – he called it “addicted to pain” (no relation to painkillers). Now this appears to be driven by increased white matter circuitry from … Continue reading
Posted in Insurer issues, pain mechanisms, Pathophysiology
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Effect Of Cushioning Insoles on Workplace Back, Foot and Knee Pains
Use of sorbothane insoles cut back pains by 38%, foot pains by 37% and knee pains by 38%. Relief in back pain did not mean relief in another areas. Wonder if antifatigue covers would help more.
Posted in Back Pain, Knee, Leg Pains, Mechanical aids
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