Recent study demonstrated more favorable response to ketamine for depression if B12 levels are higher. I have been giving 1000 mcg/week IM and perhaps that is wise..
Pharmacopsychiatry. 2013 Sep;46(6):227-8.
Vitamin B12 level may be related to the efficacy of single ketamine infusion inbipolar depression.
Permoda-Osip A, Dorszewska J, Bartkowska-Sniatkowska A, Chlopocka-Wozniak M, Rybakowski JK
- single infusion
- “We estimated the serum levels of these substances in 20 bipolar depressed patients before ketamine infusion.
- “10 patients responded favorably to this procedure, as their score on the Hamilton depression rating scale, compared to baseline, was reduced by more than 50%, after 7 days.”
- “The vitamin B12 level was significantly higher in “responders” compared to the remaining patients.”
Confirms my use of B12 in depressed patients – I do think that injectable is needed as absorption can be poor (at least initially)