Fibromyalgia rates are much higher in Hashimoto’s thyroiditis (HT) – about 31% and not higher in cases with subclinical hypothyroidism. This suggests a subgroup might be autoimmune.
Rheumatol Int. 2010 Nov 18. [Epub ahead of print]
Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia?
Bazzichi L, Rossi A, Zirafa C, Monzani F, Tognini S, Dardano A, Santini F, Tonacchera M, De Servi M, Giacomelli C, De Feo F, Doveri M, Massimetti G, Bombardieri S. abstract here
- Controls with subclinical hypothyroidism had a 0% FM rate
- Hashimoto’s Thyroiditis with subclinical hypothyroidism had a 28.5% FM rate
- Hashimoto’s Thyroiditis without subclinical hypothyroidism had a 33% FM rate
Thyroid antibodies levels in FM subjects were 10-20 times higher than normals or just subclinical hypothyroid cases.
Comment – I wrote previously about the association of thyroid antibodies and muscle pains – associated with dry eyes and mouth and throid antibodies:
Muscle-Joint Pains, Dry Mouth and Eyes? – Maybe You Have DEMS/SAPS with Thyroid Antibiodies
Those with dry eyes and dry mouth syndrome “DEMS” one has muscle aches and thyroid antibodies that no one could explain.
The fact that thyroid antibodies are higher in FM is not new – just forgotten by a generation of doctors who would like to assume FM is psychological. It has resurfaced now, and I hold better hope for the new generation of doctors not being as jaded.
Where will it end? check my FM subsection here:
FM is a central sensitization disorder with excessive brain glutamate function
FM might be a viral disease
A FM subset has hypermobility syndrome
FM might be a mast cell disease with excessive amounts in skin and bowel
FM might be a sleep disorder with sleep genes found
FM in some cases is genetic
There appears an association with bipolar disease.
It is a small fiber neuropathy.
And now a subset might be an autoimmune disease
When it’s worked out, it will be a multitude of diseases using a similar pathway to disease…
The fact that subclinical hypothyroidism was not associated with FM was interesting.