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Category Archives: neuropathic
Nerve Pain? – 21st Century Gene Therapy
Since the early 2000’s experiments gene therapy experiments have been done on rodents using a non-replicating (Not growing) version of Herpesvirus (cold sore virus). The virus’s genetic machinery has been altered so it makes ingredients for enkephalins (spine cord morphine-like … Continue reading
Posted in neuropathic
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Ounce of Prevention is a Pound of Cure For Neuropathic Pain
Chronic administration of minocycline (a tetracycline antibiotic) started 7 days prior to nerve injury prevented neuropathic pain in the animal model – This offers exciting possibilities for preventing post surgical pain conditions.
Posted in neuropathic
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Post-mastectomy Neuropathic Pain Cure – Lymph Node Transplants
Pain post mastectomy can be an important issue. Associated with the pain is swelling called lymphedema. Now it appears transplanting lymph nodes from the groin can resolve the pain and lymphedema
Posted in neuropathic
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IV Magnesium Studies
There was recent mention on using IV Magnsium in acute migraines in a previous blog note. I had used it in combination 1-2 gms Magnesium sulphate with lidocaine 100 – 200mg IV for migraines but was not impressed that it … Continue reading
Posted in IV therapy, neuropathic
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New Hopes for Leg Phantom Limbs
Phantom limb pain is suprizingly resistant to treatment and some articles on the subject have concluded “put them on opioids – perhaps methadone”. Now come two different approaches to treating the leg version of this – memantine and pulsed radioifrequency.
Posted in neuropathic
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Acute Nerve Injury – Try Gabapentin and Tramadol
After a sciatic nerve as accidentally injected, gabapentin and tramadol helped the pain until some recovery came about.
Posted in Drugs, neuropathic
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Diabetic Peripheral Neuropathy – Pregabalin to 600mg or bust
I am used to 75-150 mg doses of pregabalin but doses of 300 mg BID are being used for diabetic peripheral neuropathy.
Posted in Drugs, neuropathic
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Neuropathic Pain More Spinal and there are potentially better treatments
Recent Japanese article hilights spinal sensitization in neuropathic pain suggesting lidocaine and ketamine maybe should play bigger role
Posted in neuropathic, Pathophysiology
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Fast Fix for Shingles Pain – and Doctors: For God’s Sake – Give a Block!
Nerve blocks combined with tricyclic antidepressants gave rapid relief of pain in 80% cases in one Japanese report. I feel nerve blocks or epidural blocks are manditory for any cases of shingles in which the current acutely infected pain would … Continue reading
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Super Capsaicin for Neuropathic Pain Control Looks Promising
The use of a SINGLE application of a 8% (vs 0.025 – 0.075 usually used) capsaicin patch (NGX-4010) resulted in significant relief for over 12 weeks in HIV neuropathic pain. Given the old technique (4 X/day gel application for two … Continue reading
Posted in neuropathic, Topical Pain Treatments
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Microglia Key to Neuropathic Pain
While much is written about gimped NMDA receptors in chronic pain, the innocuous support tissues in the spinal cord, the “glial cells”, turn out to be a big player. An inhibitor of these cells, clopidogrel – known as Plavix – … Continue reading
Posted in neuropathic, Pathophysiology
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Post Hernia Surgery Helped by TENS and Should Surgeons be Doing Hernia Repairs if They do Not Know How to Deal with the Persistent Pain Afterwards?
Pain after hernia surgery is common. Transcutaneous nerve stimulation (TNS) seems to help post operatively and one wonders if it might have lasting effects. I was always taught that one should not do a procedure unless one can deal with … Continue reading
Posted in neuropathic, Post Hernia
40 Comments
Pamidronate and Clodronate – hope for CRPS and Back Pain
Pamidronate can significantly help over 3/4 of RSD and reduce chronic back pain through a series of simple infusions. It is expensive and because of a poorly designed negative study, has not reached full acceptance for the good it can … Continue reading
Posted in complex regional pain, IV therapy, neuropathic
12 Comments
Etanercept (Enbrel) for Radiculitis (Sciatica)
The common and disabiling pain condition is chronic lumbar radiculopathy (chronic back pain/Sciatica). Despite the widespread promotion of treatments of neuropathic pain a recent analysis of neuropathic pain treatments has concluded the following: “To date, no medications have demonstrated efficacy … Continue reading
Posted in Back Pain, Drugs, Neck, neuropathic, radiculitis
35 Comments
Varicella shots for shingles but tests ?useless
In 2005, a super-potent varicella-zoster vaccine established a 50% reduction in shingles over a 3 year period but left disturbing issues over whether the increased strength was necessary or a marketing ploy. Recent Zoster immunity testing locally cast doubt on … Continue reading
Posted in neuropathic
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