I am used to 75-150 mg doses of pregabalin but doses of 300 mg BID are being used for diabetic peripheral neuropathy.
BMC Neurol. 2008 Sep 16;8(1):33.
Efficacy and safety of pregabalin 600 mg/d for treating painful diabetic peripheral neuropathy: a double-blind placebo-controlled trial. Arezzo JC, Rosenstock J, Lamoreaux L, Pauer L
1) DM peripheral neuropathy occurs in 20% of diabetics and in 50% of cases that have had DM > 25 years.
2) they list symptoms as:
- numbness or weakness in the feet and hands
- severe dysesthetic burning with nighttime worsening
- anxiety or depression
3) Peripheral edema was 10-17% which is disturbing since diabetic agents that cause edema are associated with increased heart failure. It always bothers me how there is a big push to max doses – and then side effects show up and it’s gone. I hope this does not happen here.
4) They found the BID dosing much more convenient than TID.
5) Response rate? – 49% vs 23% in controls