Over and over again Biphosphonates have been shown to help CRPS except one study that only bothered to give one infusion. A new agent not yet available in Canada, Neridronate, at 100 mg given FOUR times over 10 days was found to reduce pain over 50% in 73% cases versus 32% in placebo. The nature review article felt this was “estimated to be equivalent to pamidronate at 90 mg given FOUR times over 4–10 days”. As previously shown, the infusions have to be given repeatedly not like a previous stupid one infusion only study.
Nature Reviews Rheumatology. 2013 Jan 29. [Epub ahead of print]
Therapy: Bisphosphonates for early complex regional pain syndrome.
Littlejohn G. no abstract
In response to article:
Rheumatology (Oxford). 2012 Nov 30. [Epub ahead of print]
Treatment of complex regional pain syndrome type I with neridronate: a randomized, double-blind, placebo-controlled study.
Varenna M, Adami S, Rossini M, Gatti D, Idolazzi L, Zucchi F, Malavolta N, Sinigaglia L. abstract here
Will write more on this later
Comment – if I could only get drug plan to listen to this.