Ibuprofen an Alternative For Preventing High Altitude Sickness

  • “Severe high altitude headache  occurred in 3% treated with ibuprofen and 10% with placebo”

PLoS One. 2017 Jun 20;12(6):e0179788. doi: 10.1371/journal.pone.0179788.
eCollection 2017.
Efficacy of ibuprofen on prevention of high altitude headache: A systematic
review and meta-analysis.
Xiong J
https://www.ncbi.nlm.nih.gov/pubmed/28632763

  • usual dose was 600 mg three times daily (max with ibuprofen is 2400 mg)
  • analysis:

Comment – I usually give Diamox 250 mg od and is as effective as a higher dose:
Low, Emma V., et al.
Identifying the lowest effective dose of acetazolamide for the prophylaxis of acute mountain sickness: systematic review and meta-analysis.
bmj 345 (2012): e6779.
http://www.bmj.com/content/345/bmj.e6779

dexamethasone has been used as well. Dose has been 8 mg twice daily:
Maggiorini, Marco, et al.
Both tadalafil and dexamethasone may reduce the incidence of high-altitude pulmonary edemaa randomized trial.
Annals of Internal Medicine 145.7 (2006): 497-506.
https://www.med.unc.edu/emergmed/files/highaltitudesickness.pdf

Comment – with people with lung issues, Diamox and dexamethasone might be better but if headache is the concern, Diamox and Ibuprofen should suffice.

 

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