Chemotherapy Induced Sore Mouth Mucositis – Cut Pain in Half with Topical Ketamine

Must be horrible to have a sore mouth with chemotherapy – ketamine  20 mg/5ml used four times daily reduced pain from 6 to 3 within days.

Support Care Cancer. 2017 Jul;25(7):2215-2219. doi: 10.1007/s00520-017-3627-6.
Treatment of severe mucositis pain with oral ketamine mouthwash.
Shillingburg A et al

  • 5 ml bottle of ketamine 100 mg/ml diluted to 20 mg/5ml with normal saline
  •  swish and spit 4 times daily
  • gargling allowed but no swallowing
  • no eating or drinking for 30 min after
  • rest pain dropped from 6/10 t0  3 after 3 days
  • pain swallowing dropped from 9/10 to 4 after 3 days
  • sleep improved
  • opioid use dropped

Comment – I think the methylene blue was better:
New Effective Treatment for Intractable Sore Mouth Mucositis

but this is an alternative


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