Cytokine (Immune chemical) diseases will become more clear in the ensuing years. Recently Tension headache was associated with higher Interleukin-6 levels.
Cytokines have become the wild card in 21st century diseases:
Diabetes type II and cytokines:
Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
Joachim Spranger,1,2 Anja Kroke,3 Matthias Mo¨ hlig,1,2 Kurt Hoffmann,3 Manuela M. Bergmann,3 Michael Ristow,1,2 Heiner Boeing,3 and Andreas F.H. Pfeiffer1,2
Diabetes 52:812–817, 2003 free article here
Ann N Y Acad Sci. 2009 Feb;1153:240-6.
The role of neuroimmunomodulation in Alzheimer’s disease.
Maccioni RB, Rojo LE, Fernández JA, Kuljis RO. abstract here
World J Gastroenterol. 2010 June 21; 16(23): 2867–2872.
Inflammation and immunosuppression in severe acute pancreatitis
Marja-Leena Kylänpää, Heikki Repo, and Pauli Antero Puolakkainen free article here
BMC Res Notes. 2010; 3: 156.
Proinflammatory cytokine levels in fibromyalgia patients are independent of body mass index
Maria E Hernandez,1 Enrique Becerril,1 Mayra Perez,2 Philippe Leff,3 Benito Anton,3 Sergio Estrada,2 Iris Estrada,2 Manuel Sarasa,4 Enrique Serrano,5 and Lenin Pavon1 free article here
High Plasma Levels of MCP-1 and Eotaxin Provide Evidence for an Immunological Basis of Fibromyalgia
ZHIFANG ZHANG,* GREGORY CHERRYHOLMES,* ALLEN MAO,* CLAUDIA MAREK,
JEFFREY LONGMATE, MICHAEL KALOS,§ R. PAUL ST. AMAND AND JOHN E. SHIVELY*
Experimental Biology and Medicine > Volume 233, Number 9 > Pp. 1171-1180 free article here
Am J Gastroenterol. 2010 Apr 20. [Epub ahead of print]
Plasma Cytokine Profiles in Females With Irritable Bowel Syndrome and Extra-Intestinal Co-Morbidity.
Scully P, McKernan DP, Keohane J, Groeger D, Shanahan F, Dinan TG, Quigley EM.
Brain Behav Immun. 2010 May 4. [Epub ahead of print]
A formal analysis of cytokine networks in Chronic Fatigue Syndrome.
Broderick G, Fuite J, Kreitz A, Vernon SD, Klimas N, Fletcher MA. abstract here
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Jun 20. [Epub ahead of print]
Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression.
Maes M. abstract here
And present article re Tension headaches:
Clin J Pain. 2010 Jul 20. [Epub ahead of print]
Interleukin-6 Levels in Tension Headache Patients.
Koçer A, Koçer E, Memişoğullar R, Domaç FM, Yüksel H. abstract here
In chronic tension headaches, the levels are 8 times as high. Things are so inflamed, nothing can shut it off. I tried on patient with semineurolytic lidocaine to trigger points in tension headaches. She felt wonderful for a few days, then the headaches can back – nothing can shut the triggers off when the inflammation is so high.
What decreases the cytokines?
- less stress
Psychoneuroendocrinology. 2005 Feb;30(2):188-98.
Stress-induced changes in LPS-induced pro-inflammatory cytokine production in chronic fatigue syndrome.
Gaab J, Rohleder N, Heitz V, Engert V, Schad T, Schürmeyer TH, Ehlert U. abstract here
Aquatic exercise improves the monocyte pro- and anti-inflammatory cytokine production balance in fibromyalgia patients
E. Ortega 1 , M. E. Bote 1 , E. Giraldo 1 , J. J. García
Scandinavian Journal of Medicine & Science in Sports in press 2010 abstract here
Cytokine Inhibition for Treatment of Alzheimer’s Disease
- Meditation and Tai Chi –
Changes in cytokine production in healthy subjects practicing Guolin Qigong : a pilot study
Brian M Jones
BMC Complementary and Alternative Medicine 2001, 1:8 free article here
- Azelastine Hydrochloride – a mast cell stabilizing anti-allergy med:
Inhibition of cytokine production from human peripheral blood leukocytes by anti-allergic agents in vitro
Shin-ichi Konno a,,, Kazuhito Asano b, Ken-ichi Okamoto b, Mitsuru Adachi a
European Journal of Pharmacology 264 (1994) 265-268 abstract here
- Glutathione agents – that includes SAMe, methionine, Coenzyme Q10, alpha lipoic acid. See:
What Can One Do For Low Glutathione Levels
Treatment With Glutathione Precursor Decreases Cytokine Activity
Luis R. Pena
Journal of Parenteral and Enteral Nutrition 23:1-6, 1999 abstract here
- Lose weight:
Higher body mass index (BMI) is associated with reduced glucocorticoid inhibition of inflammatory cytokine production following acute psychosocial stress in men
Psychoneuroendocrinology, Volume 33, Issue 8, September 2008, Pages 1102-1110
Petra H. Wirtz, Ulrike Ehlert, Luljeta Emini, Tobias Suter abstract here
- Good sleep:
Brain Behav Immun. 2010 Jul 22. [Epub ahead of print]
Sleep Depth and Fatigue: Role of Cellular Inflammatory Activation.
Thomas KS, Motivala S, Olmstead R, Irwin MR. abstract here
- Get any sleep apnea/ disturbed sleep treated even if not drowsy during day:
Sleep Breath. 2007 Sep;11(3):177-85.
Inflammatory proteins in patients with obstructive sleep apnea with and without
Bravo Mde L, Serpero LD, Barceló A, Barbé F, Agustí A, Gozal D. abstract here