Attenuation of Pain After Spinal Injury May be Possible

Microglia spinal support nerves become activated after nerve and spinal injury an greatly potential the pain. Animal experiments show minocycline, a tetracycline antibiotic known to inhibit microglia, can reduce post spinal pain in animal subjects.

Previously I have discussed how microglia are important in causing chronic pain:
Microglia Key to Neuropathic Pain link here

I also discussed how minocycline prevents neuropathic pain after nerve injury in animals by inhibiting microglia:
Ounce of Prevention is a Pound of Cure For Neuropathic Pain link here

Now further benefit shown here:

J Rehabil Res Dev. 2009;46(1):123-33.
Early microglial inhibition preemptively mitigates chronic pain development after experimental spinal cord injury.
Tan AM, Zhao P, Waxman SG, Hains BC abstract here

  • Rats – thoracic level spinal injury
  • minocycline for 5 days post injury
  • This reduced microglia activation
  • There was both behavioural and electrophysiological evidence of reduced pain

Comment – For oral use, doxycycline 100 mg twice daily could be used instead and is safer than minocycline, which can cause lupus and liver damage. However, a five day course would be less of a concern. One of the new concepts in chronic pain is that of “pain memory” – a seed is set in memory that the chronic pain can grow on. It seens to me the spinal cord micorglia activation is part of that. I can see in the future use of microglia inhibitors such as these tetracycline given prior to surgery and after spinal cord injuries. I wonder if whiplash would fall in there somewhere as well…


Use of TNF inhibitor, Entanercept, resulted in markd deminution of mechanical allodynia in animal models post spinal cord injury:

Eur J Pain. 2009 Aug;13(7):673-81. Epub 2008 Oct 11.

Effects of Etanercept and Minocycline in a rat model of spinal cord injury.

Marchand F, Tsantoulas C, Singh D, Grist J, Clark AK, Bradbury EJ, McMahon SB.

abstract here

I wonder how long it will take for these treatments to become used in humans?

Any comments? canada goose outlet canada goose outlet

This entry was posted in Drugs, pain mechanisms. Bookmark the permalink.

One Response to Attenuation of Pain After Spinal Injury May be Possible

  1. Pingback: Pain Medical Musing » Blog Archive » What Does One Do To Prevent Post Surgery Pains?

Leave a Reply

Your email address will not be published.