I have previously written:
Does Pain “Grow” at Tendon injury sites? -and Treatment tennis elbow
Now for shoulder tendonopathy, “increases of newly grown nerve fibers and blood vessels ” inside tendons has been found
Sports Med Arthrosc. 2011 Dec;19(4):354-9.
Neoinnervation in rotator cuff tendinopathy.
Xu Y, Bonar F, Murrell GA. abstract here
- [various biochemical markers and staining for nerve fibers demonstrate] “that early tendinopathy is associated with increases of newly grown nerve fibers and blood vessels inside and around tendinopathic tendon”
- So angiogenesis and nerve fiber growth can become a new target for treatment of these conditions. Certainly, in models of arthritis, it has been found to play a major role:
Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis.
Ashraf S. Mapp PI. Walsh DA.
Arthritis & Rheumatism. 63(9):2700-10, 2011 Sep.