Malassezia Fungus Makes News Again With Peptic Ulcers

Malassezia seen in brains of Alzheimer’s:
Front Aging Neurosci. 2018 May 24;10:159. doi: 10.3389/fnagi.2018.00159
Infection of Fungi and Bacteria in Brain Tissue From Elderly Persons and Patients With Alzheimer’s Disease.
Alonso R et al.
“the fungal genera more prevalent in AD patients were Alternaria, Botrytis, Candida, and Malassezia”

and, in abundance, in pancreatic ca:
Aykut, Berk, Smruti Pushalkar, Ruonan Chen, Qianhao Li, Raquel Abengozar, Jacqueline I. Kim, Sorin A. Shadaloey et al.
The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL.
Nature (2019): 1-4.

“Here we show that fungi migrate from the gut lumen to the pancreas, and that this is implicated in the pathogenesis of PDA [Pancreatic Duct Cancer].  PDA tumours in humans and mouse models of this cancer displayed an increase in fungi of about 3,000-fold compared to normal pancreatic tissue.

Now, seborrheic dermatitis, related to it, increases chance of peptic ulcers by 1.6 times.


Chen, Tai‐Li, et al.
Seborrheic dermatitis and risk of incident peptic ulcer disease: A nationwide population‐based cohort study.
Australasian Journal of Dermatology 62.4 (2021): e546-e553.

Comment –  resistant peptic ulcers, in patients with seborrhea, might benefit from treatment with fluconazole

I would try flucanazole 100 mg 1/2 tab bid x 2 weeks as 50 mg/day only 74% effective:
Zisova, Lilija G.
Fluconazole and its place in the treatment of seborrheic dermatitis–new therapeutic possibilities.
Folia medica 48.1 (2006): 39-45.

Have used it myself and can verify it takes 2 weeks and might come back some after 3 months…

Have a peptic ulcer that won’t go away – consider fungal treatment. Theoretically, treatment with antibiotics for helicobacter, might increase fungal presence…



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