What are the Causes of Polyneuropathy?

Recent study gave a breakdown of what they found re cause. Frank diabetes was eliminated from selection as the cause would be obvious? Top 4 were Idiopathic 47%, Chronic Demyelinating Inflammatory Polyneuropathy(CIDP) 38%, Pre-diabetes 16%, and Charcot Marie Tooth syndrome (CMT) 9%.

Toronto Clinical Neuropathy Score is valid for a wide spectrum of polyneuropathies
A. Abraham et al
European Journal of Neurology 2018, 25: 484–490

Table 2 Etiologies for polyneuropathy in 151 patients; () are per cent
Idiopathic 47 (31)
Chronic inflammatory demyelinating polyneuropathy (CIDP) 38 (25)
Pre-diabetes 16 (11)
Charcot–Marie–Tooth (CMT)  9 (6)
Chemotherapy 8 (5)
MMN multifocal motor neuropathy 6 (4)
Monoclonal gammopathy of undetermined significance (MGUS) 4 (3)
Myelin-associated glycoprotein (Anti-MAG) 4 (3)
B12 deficiency 4 (3)
Renal 2 (1)
Alcohol 2 (1)
hereditary neuropathy with liability to pressure palsies (HNPP) 1 (1)
Miscellaneous 10 (7)
Miscellaneous includes connective
tissue disorders, vasculitis, amyloidosis, dorsal root ganglionopathy,
human immunodeficiency virus and lymphoproliferative disorders.
Data are given as n (%).

Diabetes o

CIDP usually has both motor and sensory changes with typical EMG.   Loss of ankle jerks, and elevated CSF proteins are typical

MGUS show a elevated band on protein electrophoresis

Anti-MAG has sensory ataxia and motor weakness. Elevated IgM monoclonal levels, elevated cerebral spinal fluid proteins, and Anti-MAG antibodies

MMN multifocal motor neuropathy – presents with muscle weakness and cramps and muscle atrophy. Might have muscle twitching like seen in ALS.  EMG and serology for GM1 antibodies for diagnosis



This entry was posted in neuropathic. Bookmark the permalink.

Leave a Reply

Your email address will not be published.