Confirmed – Resistant Ulcerative Colitis – Fecal Transplant Works 1/2 Time

70%  showed clinical response, and “13 of the 30 (43.3%) patients achieved clinical and endoscopic remission.”

Medicine (Baltimore). 2017 Apr;96(16):e6479.
doi: 10.1097/MD.0000000000006479.
Fecal microbiota transplantation is a rescue treatment modality for refractory ulcerative colitis.
Uygun A
https://www.ncbi.nlm.nih.gov/pubmed/28422836

  • make point of saying “an overall cure rate of over 80% in treatment of refractory or recurrent Clostridium difficile infection.”
  • Turkish study
  • screened for  Salmonella, Shigella, E. coli, Campylobacter, Yersinia, C. difficile by the polymerase chain reaction, and parasites) and serologic tests (i.e., hepatitis A IgM, HBsAg, anti-HCV, anti-HIV I-II, CMV IgM, EBV IgM, syphilis VDRL/TPHA tests.
  • Procedure verbatim:
    bowel lavage (500mL sennoside a+b calcium and 2L water) for colonoscopy preparation on the day before FMT.   The median amount of 120 to 150g donor feces was used for FMT preparation. Donors were instructed to collect feces in a small container and to bring it to the hospital on the day of the scheduled transplant. Thus, fresh stool material was used in this study. A total of 500mL extracted fecal suspension was prepared with 500mL 0.9% NaCl using the conventional blender and divided into 50mL syringes. Filtered fecal microbiota suspension was administered into the 30 to 40cm proximal of terminal ileum of recipients through endoscopic infusion catheter inserted into the colonoscopy under anesthesia. Loperamide was given to all patients to decrease intestinal transit time and to create accurate time for colonization of donor intestinal flora 3 hours before FMT.”
  • judged effect by how was at 12 weeks
  • 43.3% of patients with refractory UC achieved clinical endoscopic, and laboratory remission
  • additional 26.7% achieved a clinical response
  • meta- analysis of clinical remission inpatients with UC was 30.4%.
    Sun D, Li W, Li S, et al. Fecal microbiota transplantation as a novel therapy for ulcerative colitis: a systematic review and meta-analysis. Medicine (Baltimore) 2016;95:e3765
  • recent meta-analysis –  40.5% patients with UC achieved clinical remission and 66.1% achieved clinical response.
    Shi Y, Dong Y, Huang W, et al. Fecal microbiota transplantation for ulcerative colitis: a systematic review and meta-analysis. PLoS One 2016;11:e0157259.

Comment – got ulcerative colitis? – I would be eyeing my relatives for one with the best bowels…

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