High proportion of cases of Fibromyalgia (FM) and Chronic fatigue subjects had sleep studies and HLA body marker abnormalities suggestive of narcolepsy and responded to Sodium Oxybutate
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Treatment of the Narcoleptiform Sleep Disorder in Chronic Fatigue Syndrome and Fibromyalgia with Sodium Oxybate
A. Robert Spitzer, MD*; Melissa Broadman, DO, MPH�
Pain Practice, Volume 10, Issue 1, 2010 54–59 free article here
The group used was discussed earlier under:
Do Some Victims with Fibromyalgia(FM) and Chronic Fatigue Syndrome(CFS) Have Sleep Genes?
- Oxybutate treatment is capable of reaching stages 3-4 deep restorative sleep
It was discussed prior here:
3rd Retrovirus to Infect Humans Found in Fibromyalgia and Chronic Fatigue -Not Confirmed But Possibly Because Poor Techniques Used - HLA markers associated with narcolepsy – HLA DQB1-0602 were obtained.
- MSLT – multiple sleep latency test – determine an averaged over 5 naps (the multiple), time to sleep. Short times indicate excessive drowsiness:
- in 73 cases (80%), the MSLT was abnormally short
- “43% were positive for HLA DQB1-0602, compared with an 8% average population prevalence
in 225 population prevalences (P < 0.0001).” – a marker type found in narcoelpsy - SOREM – Sleep onset rapid eye movements – is one way of detecting sleep and was positive in 36% of cases
- Oxybate rx – some stopped treatment because of cost
- Results:
- They worked out criteria for responsive syndrome:
Side effects of Oxybate included:
“of the 85 patients taking at least one dose of the medication:
- 50 patients(59%) reported substantial relief of pain
- 64 (75%) had significant relief of fatigue
- Forty-six (54%) had simultaneous relief of both fatigue and pain”
Comment – If you can nap on a dime and your eyes rapidly move early in the course of, then response of your FM can occur with this drug. It is expensive.
Addendum – because Oxybutate can be used as a date rape drug, in 2010, the Food and Drug Administration resoundingly rejected it for use in above disorders. At the IASP meeting in Montreal, speakers lamented there is no drug particularly effective for insomnia issues in chronic pain (sleep architecture-wise etc). Well, there is, but it will never see the light of day…
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