Injection of wild type glial brain support cells into mutant OCD grooming mice helps abate the mice’ OCD some.
Cell, Volume 141, Issue 5, 775-785, 28 May 2010
Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice
Shau-Kwaun Chen1, Petr Tvrdik1, Erik Peden1, Scott Cho2, Sen Wu1, Gerald Spangrude2 and Mario R. Capecchi
Hox genes is best known for helping embryonic organization, neural development, and pain sensitivity.
- microglia are immune infection fighting cells found in neural tissue. Some originate in the brain, some start in bone marrow and move out from there.
- Mice deficient in Hoxb8 excessively groom
- This excessive grooming is cut back by bone marrow injections from wild type mice (not a cure though).
- Injecting bone marrow glial cells from Hoxb8 deficient to wild type, starts up OCD grooming
Comment – It appears the immune system impacts OCD and one would wonder about other neuropsychological conditions. This has exciting posibilities and opens up an entirely new avenue of treatments. I have discussed the link between microglia and chronic pain before here:
One of the letters commented on the microglial link with asperger’s syndrome (social incompetence) and schizophrenia.