Dry eyes was significantly improved by repeated injections of platelet rich plasma around lacrimal gland
Cornea. 2014 Jan;33(1):18-21.
Restoration of human lacrimal function following platelet-rich plasma injection.
Avila MY.
http://www.ncbi.nlm.nih.gov/pubmed/24240491
- “Ten milliliters of whole blood was collected by venopuncture in sterile tubes containing sodium citrate 0.5 mL (Beckton Dickenson). The blood was centrifuged at 160g for 10 minutes. The plasma was isolated (~5 mL per patient) and centrifuged again at 160g for 15 minutes. The inferior 1 mL was isolated, and 0.1 cm3 of CaCl was added to activate platelets. “
- “This fraction was injected in the external one-third of the orbital rim and 4 mm in depth to the superior area. The rference was the area of the lacrimal fossa in the frontal one. This anatomic area corresponds to the localization of
the lacrimal gland.” - Platelet rich-activated plasma (1 mL) was injected adjacent to the lacrimal gland on day 0 and at 4, 8, and 12 weeks
“RESULTS: All cases showed a significant improvement in lacrimal volume (from 3.3 +/- 0.8 mm to 11.1 ± 2.3 mm). In all the patients, an increase in tear break-up time values and a decrease in ocular staining (basal 8.0 ± 0.61-2.8 ± 0.5) with subjective improvement occurred. None of the patients presented any adverse effect, and none reported pain or discomfort. Additionally, no complications were observed.”
Comment – wow – that could change everything for dry eyes if it lasts.
addendum:
confirmed:
Avila, M. Y., Igua, A. M., & Mora, A. M. (2019).
Randomised, prospective clinical trial of platelet-rich plasma injection in the management of severe dry eye.
British Journal of Ophthalmology, 103(5), 648-653.
https://www.researchgate.net/profile/Marcel-Avila/publication/326167342_Randomised_prospective_clinical_trial_of_platelet-rich_plasma_injection_in_the_management_of_severe_dry_eye/links/5f35fd0e299bf13404c1bc92/Randomised-prospective-clinical-trial-of-platelet-rich-plasma-injection-in-the-management-of-severe-dry-eye.pdf
“PRP injection is safe and effective in improving tear parameters as well as subjective
parameters, and was found to be superior to hyaluronic acid alone in the management of patients with severe dry eye. This represent a novel alternative treatment for severe dry eye”
Sjogren syndrome cases
Method:
“For each patient on the PRP group, 10 mL of whole blood was collected by venipuncture into sterile tubes containing 0.5 mL sodium citrate (Becton Dickinson). The blood was centrifuged at 160 g for 10 min. The plasma was isolated (approximately 4.5 mL per patient) and centrifuged again at 160 g for 15 min. The bottom 1 mL was isolated and 0.1 cm 3 of CaCl was added to activate the platelets.
A 1 mL tuberculin syringe (Becton Dick- inson) with a 27G x 1/2 inch needle was used for the injection. Approximately 4 mm of the needle was introduced into the orbital rim. The area to be injected had been previously disinfected with iodopovidone and isopropanol. This fraction (1 mL) was injected transcutaneously into the external one-third of the orbital rim at a depth of 4 mm to the superior area. The reference was the area of the lacrimal fossa in the frontal bone. This anatomical area corresponds to the location of the lacrimal gland as previously described in procedures involving injection into the lacrimal gland14 (figure 2). This procedure was completed on days 0, 30, 60 and 90 in both eyes of patients in the intervention group.”
PRP also found helpful in salivary gland issues:
Dessoukey, Shaymaa Mamdouh, et al.
The Effect of Adipose Derived Stem Cells versus Platelet Rich Plasma in Ameliorating Cisplatin-Induced Injury on The Submandibular Salivary Gland. A Comparative Histological Study. Egyptian Journal of Histology 44.2 (2021): 406-417.
https://ejh.journals.ekb.eg/article_104463_d186b8c92a9714859f846e4f4a9964fa.pdf