Neuropathic Foot Pain That Nothing Else Works – New Foot Cream Mix

Recent article found relief of resistent neuropathic foot pain with a combination of 3% lidocaine, 0.075% capsiacin, and isosorbide dinitrate (ISDN) 0.4% in cream format

J Pain Symptom Manage. 2010 Feb;39(2):e9-e10.
A new combination cream for the treatment of severe neuropathic pain.
Kopsky DJ, Keppel Hesselink JM. no abstract

  • painful diabetic polyneuropathy – pain as burning, squeezing and excruciating
  • Pregabalin – not tolerate
  • PENS once a week – a little pain relief. (multiple level spinal needle acupuncture)
  • cannabis in the evening, amitriptyline 20 mg daily, alpha lipoic acid 600 mg daily, and acetyl-L-carnitine 1000 mg/day – all marginal effect
  • topical capsaicin 0.075% by self – no effect

They felt the combo effected several mechanism for pain control:

  • ISDN – vasodilate and increases NO in tissues (both decreased in neuropathy)(can cause headaches though)
  • Lidocaine – sodium channel effect – also would block the burning from capsaicin
  • Capsaicin – C pain fiber substance P depletion
  • Mix applied 3 times/day – though found worked better 4-5 times a day before pain resurged.
  • Careful washing hands after use (and no eye rubbing)
  • during first two weeks, pain went from 98/100 to 40-50/100 – varied from 30-70 in end
  • subject was able to resume activities

Comment – sounds like a good mix to me. Our compounding pharmacy in Regina is Hill Ave. Drugs

Amitriptyline and ketamine combo also used for neuropathic pain..

anyone heard of other good combos? pandora joyeria pandora joyeria

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