? Sciatica Option – Drug For Pulmonary Hypertension Gives Relief

Case study of patient on Sitaxsentan, a selective endothelin-A antagonist used in pulmonary hypertension, found his sciatica got better while on the drug and worse when off.

Am J Med. 2010 Mar;123(3):e7.
Relief of Chronic Neuropathic Pain through Endothelin Antagonism.
Murphy DM, O’Callaghan DS, Gaine SP. no abstract

  • Sitaxsentin is used for pulmonary hypertension:
    abstract here
  • Subject in this case was put on 100 mg Sitaxsentan/day.
  • “he had experienced a substantial improvement in his sciatica, allowing discontinuation of analgesia. On questioning, pain scores were reduced from 8/10 to 2/10. Unfortunately, 4 months later, despite improvement in his pulmonary arterial,
    his sitaxsentan was discontinued due to hepatic dysfunction. He reported a prompt return of his sciatica following cessation of endothelin-A antagonist therapy.”

Comment – this could be a useful treatment except for the fact not covered by our drug plan, and the liver dysfunction it can cause. There was an advisory concerning such here nike air max hombre nike air max hombre

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