Interstitial Cystitis/Painful Bladder – What are the Genetic Correlates?

Twin studies have found genetic linkages  of IC/painful bladder syndrome with several diseases – Irritable bowel,  prior physical abuse,  frequent headaches,  multiple drug allergies, and self reported bladder infections.

J Urol. 2011 Nov 14. [Epub ahead of print]
Bladder Pain Syndrome/Interstitial Cystitis in Twin Sisters.
Tunitsky E, Barber MD, Jeppson PC, Nutter B, Jelovsek JE, Ridgeway B.   abstract here

  • If one has it, 35% chance other will have IC/PB as well
  •  irritable bowel syndrome 1.8 X as likely
  • physical abuse 2.5 x as likely
  • frequent headaches 1.6 X as likely
  • multiple drug allergies 1.5  x as likely 
  • number of self-reported urinary tract infections in the last year – 8.2 x as likely

Comment – have a mother – daughter with IC/PB, IBS, headaches, multiple allergies, and repeated sterile “bladder infections” charmepascher charmepascher

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