Cure For Radiation Bladder Irritation Cystitis

Hyaluronate instillations have been used in Interstitial cystitis – now it helps in radiation cystitis

Minerva Urol Nefrol. 2010 Jun;62(2):145-50.
Efficacy of sodium hyaluronate in the management of chemical and radiation cystitis.
Sommariva ML, Sandri SD, Ceriani V.  abstract here

Cystistat, available in Canada but not the US, is used in In IC:
see ad here

It is often given weekly and costs $280.00 US dollars per weekly 50 ml vial. One supplier here

In IC, it works best after a bladder distention procedure.

There is a protocol for use for radiation cystitis,or after chemotherapy or BCG instillation:

• sodium hyaluronate, 40 mg/50 mL, weekly for from 8 to 24 weeks
• first four weeks dexamethasone 32 mg was mixed in as a “cocktail”,
• “to allow patients with marked overactive bladder to keep these drugs within the bladder, we instilled lidocaine 2% 30 mL, 30 minutes before” – this is a treatment in itself – it has been found to be very beneficial in Interstitial cystitis:
  Intra-Bladder Lidocaine Freezing to Diagnose Bladder Pain Syndromes and Lidocaine Treatments for Bladder Pain
  30 mls of 2% is 600 mg of lidocaine – I’m not sure I’d  want to use more than 10 mls but I guess they do pee most out after 30 min…
• though pain and frequency disappeared after 4 weeks, it was necessary to keep up treatments as great tendency to relapse
• bladder capacity went from 85 to 243.3 mL (P<0.0001) in the radiotherapy patients

“Overall 67 patients (97%) reported complete relief of dysuria and pain”

comment – looks good but an 8 week treatment would be $2000 dollars for just cystistat alone.