Capsaicin 8% patch was compared to pregabalin (lyrica) for effects on non-diabetic peripheral neuropathy. A treatment with Capsaicin can cut skin sensitivity (dynamic mechanical allodynia) in half and render 29% free of sensitivity. Was embarrassed to publish this once I found out how much the patch costs ($800/patch in 2012)
Eur J Pain. 2018 Apr;22(4):700-706.
Superiority of capsaicin 8% patch versus oral pregabalin on dynamic mechanical allodynia in patients with peripheral neuropathic pain.
Cruccu G et al
- 253 case of nerve injury or non-diabetic peripheral neuropathy with pain >/= 4/10
- half group was put on pregabalin 150 – 600 mg/day
- area involved determined by lightly brushing edges – marked
- can use up to 4 patches to area marked
instructions are here;
- medical office treatment
- apply a topical numbing gel – lidocaine was recommended but not convinced works that well – maybe occlude and have on 30-60 minutes
- take a painkiller -plus I would use ketamine 10 mg M deltoid once or twice every 15 minutes as I am comfortable used to using it
- wear gloves
- apply to affected areas and cover
- have on 30-60 minutes
- removed by slowly rolling edge
- apply cleansing gel and wipe off
- avoid touching eyes
- skin will be sensitive a few days
- do every 3 months
results at week 8:
Complete resolution of pain in 24.1% of patches and 12.3% of pregabalin at 8 weeks side effects were pain and eythema at time of treatment but were manageable.
Comment – would be a great addition to treatment except the cost
“One capsaicin 8% patch costs approximately $800 (US) in 2012
Groninger H, Schisler RE. Topical Capsaicin for Neuropathic Pain #255. Journal of Palliative Medicine. 2012;15(8):946-947. doi:10.1089/jpm.2012.9571.
If you need cheap, start with amitriptyline hs and work up.