Botulinum (Botox) in Animals – Works on Peripheral Nerve Injury and Not Radiculitis

In rodents were either afflicted with either:
– peripheral nerve injury – string tied about sciatic nerve
– sciatica / radiculitis – string tied about a lumbar nerve

Botox injections into paw cut senstivity by 50% in the peripheral injury but had no effect on lumbar root pain

IASP Poster Presentation Number: PH 271, Montreal 2010

DIFFERENTIAL EFFICACY OF BOTULINUM NEUROTOXIN TYPE A IN MODELS OF NEUROPATHIC PAIN

R. S. Broide, M. S. Washburn, K. R. Aoki, J. Francis, Biological Sci., Allergan Inc, Irvine, CA, USA

  • Tying a ligature around the sciatic nerve is called the “Chronic Constriction Theory”
  • Tying ligature around L5 and 6 spinal nerves was called the “Spinal Nerve Ligation Model”
  • Botox 15 units into paw had no effect of spinal nerve injury, but cut senstivity in half in sciatic nerve injury.

Comments – It was suggested that the Spinal Nerve Ligation Model pain might originate more centrally but more peripheral nerve injuries – like peripheral neuropathies and peripheral nerve injuries might respond more to botox. I have discussed its use in diabetic peripheral neuropathy here:
Botulinum / Botox for Neuralgia/Neuropathic Pain

(near bottom)

Any experience with this? air max air max

This entry was posted in Botox, pain mechanisms, post herpetic neuralgia, radiculitis. Bookmark the permalink.

Leave a Reply

Your email address will not be published.