In rodents were either afflicted with either:
– peripheral nerve injury – string tied about sciatic nerve
– sciatica / radiculitis – string tied about a lumbar nerve
Botox injections into paw cut senstivity by 50% in the peripheral injury but had no effect on lumbar root pain
IASP Poster Presentation Number: PH 271, Montreal 2010
DIFFERENTIAL EFFICACY OF BOTULINUM NEUROTOXIN TYPE A IN MODELS OF NEUROPATHIC PAIN
R. S. Broide, M. S. Washburn, K. R. Aoki, J. Francis, Biological Sci., Allergan Inc, Irvine, CA, USA
- Tying a ligature around the sciatic nerve is called the “Chronic Constriction Theory”
- Tying ligature around L5 and 6 spinal nerves was called the “Spinal Nerve Ligation Model”
- Botox 15 units into paw had no effect of spinal nerve injury, but cut senstivity in half in sciatic nerve injury.
Comments – It was suggested that the Spinal Nerve Ligation Model pain might originate more centrally but more peripheral nerve injuries – like peripheral neuropathies and peripheral nerve injuries might respond more to botox. I have discussed its use in diabetic peripheral neuropathy here:
Botulinum / Botox for Neuralgia/Neuropathic Pain
Any experience with this?