For years people were told they needed 400 u/day; Now it looks like 8000 is more like it. There are all sorts of cures for disease’s with taking vit d which is probably just making up for deficiency.
J Prev Med Public Health. 2017 Jul; 50(4): 278–281.
The Big Vitamin D Mistake
Dimitrios T. Papadimitriou
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/pdf/jpmph-50-4-278.pdf
Verbatum Text:
- “Since 2006, type 1 diabetes in Finland has plateaued and then decreased after the authorities’ decision to fortify dietary milk products with cholecalciferol.
- The role of vitamin D in innate and adaptive immunity is critical.
- A statistical error in the estimation of the recommended dietary allowance (RDA) for vitamin D was recently discovered; in a correct analysis of the data used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5% of individuals to achieve values ≥50 nmol/L.
- Another study confirmed that 6201 IU/d was needed to achieve 75 nmol/L and 9122 IU/d was needed to reach 100 nmol/L.
- The largest meta-analysis ever conducted of studies published between 1966 and 2013 showed that 25-hydroxyvitamin D levels <75 nmol/L may be too low for safety and associated with higher all-cause mortality, demolishing the previously presumed U-shape curve of mortality associated with vitamin D levels.
- Since all-disease mortality is reduced to 1.0 with serum vitamin D levels ≥100 nmol/L, we call public health authorities to consider designating as the RDA at least three-fourths of the levels proposed by the Endocrine Society Expert Committee as safe upper tolerable daily intake doses.
- This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter.
- Actions are urgently needed to protect the global population from vitamin D deficiency.”
Comment – I had trouble finding this for a patient almost like it had been forgotten and buried . One would need 50,000 units (called osto-d2 50,000 units here) weekly to get those levels. There are now tons of studies finding vit d supplementation improves pain, immunity, sleep and so forth probably because usual levels were inadequate.
addendum – taking adequate vitamin d could reduce cancer risks by 20%
https://www.medicalnewstoday.com/articles/321151.php
addendum – low vitamin d levels show increase risk of getting mononucleosis:
Maghzi, Helia, et al. “Association between acute infectious mononucleosis and vitamin D deficiency.” Viral Immunology 29.7 (2016): 398-400.
https://www.liebertpub.com/doi/abs/10.1089/vim.2016.0038
and association of high vitamin D and prevention of subsequent MS development:
Munger, Kassandra L., et al. “Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis.” Jama 296.23 (2006): 2832-2838.
https://jamanetwork.com/journals/jama/fullarticle/204651/
articles verifying MS and mononucleosis:
He, Ruirui, Yanyun Du, and Chenhui Wang. “Epstein-Barr virus infection: the leading cause of multiple sclerosis.” Signal Transduction and Targeted Therapy 7.1 (2022): 1-2.
https://www.nature.com/articles/s41392-022-01100-0
and vitamin d association:
Disanto, Giulio, et al. “Vitamin D: a link between Epstein–Barr virus and multiple sclerosis development?.” Expert review of neurotherapeutics 11.9 (2011): 1221-1224.
https://www.tandfonline.com/doi/full/10.1586/ern.11.97