Previously I wrote how metformin helps Fibromyalgia and Bipolar. It has anti-cancer properties and diabetics, just on it, live longer. Now in animal model it it cut analgesic needs by 56-73% in regard to ibuprofen, ASA, tramadol, and pregabalin in inflammatory induced pain. Is this drug great?
Anesth Analg. 2017 Apr;124(4):1317-1329. doi: 10.1213/ANE.0000000000001561.
Metformin Synergizes With Conventional and Adjuvant Analgesic Drugs to Reduce Inflammatory Hyperalgesia in Rats.
- rat hind paw was induced by an intraplantar injection of carrageenan
- metformin cut analgesic needs by
73 ± 4% for ibuprofen
62 ± 4.2% for aspirin
69 ± 5.9% for tramadol
56 ± 3.9% for pregabalin
Comment – I think it is a great drug to be on and take myself even though not diabetic. I wonder if it would reduce tolerance to opioids…