Sorry, Naltrexone works so-so in MS at 4.5 mg/day (about 1/10 a 50 mg pill)
Ann Neurol. 2010 Aug;68(2):145-50.
Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis.
Cree BA, Kornyeyeva E, Goodin DS. abstract here
resuls on pain (scaled down to out of ten):
Well, results might be statistically significant but a Pain 0.5 drop from placebo is not clinically signficant (need drop of 2).
I was disappointed in their findings on the mental health inventory improvements – a change of 6/71 was statistically significant but it doesn’t sound like a whole lot. Inventories have a way of adding a little bit better here and a little bit better there and eventually getting a whole lot better difference that is really only a little bit better. On top of that, they don’t say what made the difference – were people much more socialable or what?
I have had some MS patients try it but was never wowed by results…
any different thoughts?
Comment – this drug alone does not give clinically relevant pain relief in MS by self but could be an adjunct