Nerve injury pain can be bad – What results can you expect for Pregabalin? Recent study concludes it helps some.
Pregabalin in the treatment of post-traumatic peripheral neuropathic pain: a randomized double-blind trial
R. van Seventer, F. W. Bach, C. C. Toth, M. Serpell, J. Temple, T. K. Murphy, M. Nimour
European Journal of Neurology 2010 in press abstract here
- randomized and treated with either flexible-dose pregabalin 150-600 mg/day (n = 127) or placebo (n = 127) in an 8-week double-blind
- initiated at 150 mg/day X 1 week then 300 mg/day for 2nd wk – first dose in AM; third week could be increased to 300 mg twice daily if need be.
- helped anxiety, sleep disturbance some
- depression – down about a point on HADs -big deal
- 8.7% somnolence rate (probably less than would have been because of “flexible-dose”)
- “Adverse events led to discontinuation of 20% of patients from pregabalin and 7% from placebo”
- “Patients with DPN, PHN, radiculopathy, trigeminal neuralgia, carpal tunnel syndrome, central neuropathic pain, or complex regional pain syndromes I or II were excluded.
- Breakdown:
- Tauama 121
- Surgery 85
- Amputation 9
- Nerve injury 20
- Other 19
- Below show the drop in pain level:
Comment – well, you generally like to see a drop of in 2/10 to get excited re benefits but hey, this is at least something. Many people can live with a 4/10. Works faster and more tolerable than gabapentin. Mixtures have an additive or synergistic effect and should be tried. See : here
any comments?
any comments?