Pregabalin (Lyrica) For Post Nerve Damage Pain

Nerve injury pain can be bad – What results can you expect for Pregabalin? Recent study concludes it helps some.

Pregabalin in the treatment of post-traumatic peripheral neuropathic pain: a randomized double-blind trial
R. van Seventer, F. W. Bach, C. C. Toth, M. Serpell, J. Temple, T. K. Murphy, M. Nimour
European Journal of Neurology 2010 in press abstract here

  • randomized and treated with either flexible-dose pregabalin 150-600 mg/day (n = 127) or placebo (n = 127) in an 8-week double-blind
  • initiated at 150 mg/day X 1 week then 300 mg/day for 2nd wk – first dose in AM; third week could be increased to 300 mg twice daily if need be.
  • helped anxiety, sleep disturbance some
  • depression – down about a point on HADs -big deal
  • 8.7% somnolence rate (probably less than would have been because of “flexible-dose”)
  • “Adverse events led to discontinuation of 20% of patients from pregabalin and 7% from placebo”
  • “Patients with DPN, PHN, radiculopathy, trigeminal neuralgia, carpal tunnel syndrome, central neuropathic pain, or complex regional pain syndromes I or II were excluded.
  • Breakdown:
    • Tauama 121
    • Surgery 85
    • Amputation 9
    • Nerve injury 20
    • Other 19
  • Below show the drop in pain level:

Comment – well, you generally like to see a drop of in 2/10 to get excited re benefits but hey, this is at least something. Many people can live with a 4/10. Works faster and more tolerable than gabapentin. Mixtures have an additive or synergistic effect and should be tried. See : here
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