Chronic indigestion “dyspepsia” is a frequent medical problem and gets bad when ulcer pills fail to work. Now nighttime – bile reflux (regurgitation bile into stomach) may account for some. This is helped by agents that help bowel motility like Domperidone (motilium)
World J Gastroenterol. 2010 Feb 7;16(5):613-7.
Effect of domperidone therapy on nocturnal dyspeptic symptoms of functional
dyspepsia patients.
Chen SL, Ji JR, Xu P, Cao ZJ, Mo JZ, Fang JY, Xiao SD.
abstract here
- They picked a group with nighttime aggravation symptoms
- Put a tube down into stomach and found nighttime bile reflux from intestine into stomach
- Found reflux decreased by domperidone as was dyspepsia symptoms.
Comment – domperidone is a nice drug – doesn’t enter brain so effects are peripheral. It would help with non-acid dyspepsia worse at night and first thing in AM..
addendum – can cause dangerous arrythmias at high dose if have ECG QT abnormalities – best get an ECG and avoid if have heart problems – sorry.